CRP is mostly produced in the liver, but also in body fat. Body fat is an endocrine organ and secretes some inflammatory cytokines, stimulating the liver to produce CRP. So, in essence, obesity is the main predictor of serum CRP levels.
Interestingly the CRP of women is higher than men. This is most likely due to the amount and pattern of body fat distribution between the two sexes. Women tend to preserve fat mass more strongly than men. One study showed that an increased level of serum CRP was associated to non-alcoholic fatty liver disease, but only in women.
So, for the most part, as long as you have high body fat, you might not see a difference in your CRP levels.
2. Is fasting the "cure" for obesity?
Fasting helps you manage the anabolic/catabolic states, of the body, which can result in better blood glucose regulation and this can help with weight management, but it is not the "cure" of obesity. Fasting has not been shown to correct body composition or the starvation response (leptin dysregulation) that the obese suffer from. If anything, it can worsen these, in the obese, and this is why it's not a proper treatment for obesity.
While fasting provides a great tool for metabolic improvement, it should never be used as a primary treatment for obesity. The obese require a primary dietary intervention, not the avoidance of food through fasting and caloric restriction. The abstainment of food has never been proven to work as a viable treatment for obesity.
3. My blood glucose lowers while fasting, so it's helping me.
And every car runs best, when it's off.
If you can’t maintain a healthy blood glucose response, in the presence of food, you have work to do. You cannot live your life fasted, just to avoid blood glucose rising after eating.
High blood glucose after eating is the result of hyperglucagonemia and it is not "cured" by avoiding food. Food avoidance actually makes this problem worse in the long run. Hyperglucagonemia is controlled through proper carbohydrate restriction, daily short fasts and time.
It takes time for hyperglucagonemia to be corrected, because it requires restoring the proper pulsatile function and first phase release of insulin and that is not achieved by just lowering insulin levels. It is only achieved by reducing insulin resistance.
4. Studies must be cited in order to show "science based" information.
The facts of what's known, not studies, on human metabolism can be found in any endocrinology/biology/biochemistry book. So, you can Google anything that’s written on here and find a medical reference for further information. Better yet, go to the ‘biology/science’ section of the book store, like I do, instead of the ‘diet/wellness’ section, for real science based information.
5. When you become more insulin sensitive, your body will be more effective at managing carbohydrates.
I have read this silly belief, on the internet, many times before.
But, in reality, the more insulin sensitive the body is, the more effective it becomes at managing its glucose regulation. Not its use of carbohydrates, but it's glucose regulation. This means the body doesn’t overproduce glucose, when it’s not needed, or underproduce it when it is. This helps sustain insulin sensitivity.
Acquiring insulin sensitivity is not for the purpose of making your body “manage carbohydrates more effectively”. That’s technically impossible, as the inability to "manage carbohydrates” has never been the cause of metabolic problems. The difficulty with carbohydrate is not that the body is ineffective at managing them or it intrinsically cannot, it’s because they interfere with blood glucose homeostasis.
6. Is excess body fat a symptom of diabetes, not the cause?
The cause of diabetes is poor blood glucose regulation. Everything else occurs downstream from this. This means that insulin abnormalities, adrenal over expression, leptin under expression, the accumulation of excess body fat and the inability to lose it, the loss of lean muscle mass, fatty liver disease, etc. etc. etc. all occur after the initial chronic disruption to blood glucose homeostasis.
So both excess body fat and diabetes are symptoms of poor blood glucose regulation. Nothing else.
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